Protein supplementation changes gut microbial diversity and derived metabolites in subjects with type 2 diabetes

Protein supplementation changes gut microbial diversity and derived metabolites in subjects with type 2 diabetes

Blog Article

Summary: High-protein diets are promoted for individuals with type 2 diabetes (T2D).However, effects of dietary protein interventions on (gut-derived) metabolites in T2D remains understudied.We therefore performed a multi-center, randomized-controlled, isocaloric protein intervention with 151 participants following either 12-week high-protein (HP; 30Energy %, N = 78) vs.low-protein (LP; 10 Energy%, N = 73) diet.Primary objectives were dietary effects on fg42 replica glycemic control which were determined via glycemic excursions, continuous glucose monitors and HbA1c.

Secondary objectives were impact of diet on gut microbiota composition and -derived metabolites which were determined by shotgun-metagenomics and mass spectrometry.Analyses were performed using delta changes adjusting for center, orbit atomizer baseline, and kidney function when appropriate.This study found that a short-term 12-week isocaloric protein modulation does not affect glycemic parameters or weight in metformin-treated T2D.However, the HP diet slightly worsened kidney function, increased alpha-diversity, and production of potentially harmful microbiota-dependent metabolites, which may affect host metabolism upon prolonged exposure.